Publicaciones

Publicaciones (*autor correspondiente)

1.   Dagnino-Subiabre A, Terreros G, Carmona-Fontaine C, Zepeda R, Orellana JA, Díaz-Véliz G, Mora S, Aboitiz F. Chronic stress impairs acoustic conditioning more than visual conditioning in rats: morphological and behavioural evidence. Neuroscience. 2005, 135(4):1067-74.

2. Orellana JA, Palacios-Prado N, Sáez JC. Chlorpromazine reduces the intercellular communication via gap junctions in mammalian cells. Toxicol Appl Pharmacol. 2006, 213(3):187-97.

3. Dagnino-Subiabre A, Orellana JA, Carmona-Fontaine C, Montiel J, Díaz-Velíz G, Serón-Ferré M, Wyneken U, Concha ML, Aboitiz F. Chronic stress decreases the expression of sympathetic markers in the pineal gland and increases plasma melatonin concentration in rats. J Neurochem. 2006, 97(5):1279-87.

4. Retamal MA, Schalper KA, Shoji KF, Orellana JA, Bennett MV, Sáez JC. Possible involvement of different connexin43 domains in plasma membrane permeabilization induced by ischemia-reperfusion. J Membr Biol. 2007, 218(1-3):49-63.

5. Schalper KA, Palacios-Prado N, Orellana JA, Sáez JC. Currently used methods for identification and characterization of hemichannels. Cell Commun Adhes. 2008, 15(1):207-18.

6. Orellana JA*, Sáez PJ, Shoji KF, Schalper KA, Palacios-Prado N, Velarde V, Giaume C, Bennett MV, Sáez JC. Modulation of brain hemichannels and gap junction channels by pro-inflammatory agents and their possible role in neurodegeneration. Antioxid Redox Signal. 2009, 11(2):369-99.

7. Schalper KA, Orellana JA, Berthoud VM, Sáez JC. Dysfunctions of the diffusional membrane pathways mediated by hemichannels in inherited and acquired human diseases. Curr Vasc Pharmacol. 2009, 7(4):486-505.

8. Sánchez HA, Orellana JA, Verselis VK, Sáez JC. Metabolic inhibition increases activity of connexin-32 hemichannels permeable to Ca2+ in transfected HeLa cells. Am J Physiol Cell Physiol. 2009, 297(3):C665-78.

9. Froger N, Orellana JA, Ezan P, Amigou E, Sáez JC, Giaume C. Cannabinoids prevent the opposite regulation of astroglial connexin43 hemichannels and gap junction channels induced by pro-inflammatory treatments. J Neurochem. 2009, 111 (6):1383-1397.

10. Orellana JA*, Hernández DE, Ezan P, Velarde V, Bennett MV, Giaume C, Sáez JC. Hypoxia in high glucose followed by reoxygenation in normal glucose reduces the viability of cortical astrocytes through increased permeability of connexin 43 hemichannels. Glia. 2010, 58(3):329-43.

11. Sáez JC, Schalper KA, Retamal MA, Orellana JA, Shoji FK, Bennett MVL. Cell membrane permeabilization via connexin hemichannels in living and dying cells. Exp Cell Res. 2010, 316(15): 2377-2389.

12. Froger N, Orellana JA, Amigou E, Kozoriz MG, Naus C, Sáez JC, Giaume C. Inhibition of cytokine-induced connexin43 hemichannel activity in astrocytes is neuroprotective. Mol Cell Neurosci. 2010, 45(1):37-46.

13. Orellana JA*, Figueroa XF, Sánchez HA, Contreras-Duarte S, Velarde V and Sáez JC. Hemichannels in the neurovascular unit and white matter under normal and inflamed conditions. CNS Neurol Disord Drug Targets. 2011, 10(3):404-414.

14. Orellana JA*, Shoji KF, Abudara V, Ezan P, Amigou E, Sáez PJ, Jiang JX, Naus CC, Sáez JC and Giaume. Amyloid β-induced Death In Cultured Neurons Involves Glial and Neuronal Hemichannels. J Neurosci. 2011, 31(13):4962-4977.

15. Orellana JA*, Díaz E, Schalper KA, Vargas AA, Bennett MV and Sáez JC. Cation permeation through connexin 43 hemichannels is cooperative, competitive and saturable with parameters depending on the permeant species. Biochem Biophys Res Commun. 2011, 17;409(4):603-9.

16. Orellana JA*, Froger N, Ezan P, Jiang JX, Bennett MVL, Naus CC, Giaume C and Sáez JC. ATP and glutamate released via astroglial connexin43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels.  J Neurochem. 2011, 118(5):826-40.

17. Orellana JA*, Sáez PJ, Cortés-Campos C, Elizondo RJ, Shoji KF, Contreras-Duarte S, Figueroa V, Velarde V, Jiang JX, Nualart F, Sáez JC and García MA. Glucose Increases Intracellular Free Ca2+ in Tanycytes via ATP Released Through Connexin 43 hemichannels.  Glia. 2012. 60(1):53-68.

18. Koulakoff N, Mei X, Orellana JA, Sáez JC and Giaume C. Glial connexin expression and function in the context of Alzheimer’s disease.  Biochim Biophys Acta. 2012. 1818(8):2048-57.

19. Orellana JA*, Sánchez HA, Schalper KA, Figueroa V and Sáez JC. Intercellular calcium signaling through connexin-based channels. Adv Exp Med Biol. 2012. 2012; 740:777-94.

20. Orellana JA*, von Bernhardi R, Giaume C and Sáez JC. Glial hemichannels and their involvement in aging and neurodegenerative diaseases. Rev Neuroscience. 2012. 23(2):163-77.

21. Eugenin EA, Basilio D, Sáez JC, Orellana JA, Raine CS, Bukauskas F, Bennett MV, Berman JW. The role of gap junction channels during physiologic and pathologic conditions of the human central nervous system. J Neuroimmune Pharmacol. 2012. 7(3):499-518.

22. Herrera-Molina R, Flores B, Orellana JA, von Bernhardi R. Modulation of interferon-γ-induced glial cell activation by transforming growth factor β1: A role for STAT1 and MAPK pathways. J Neurochem. 2012. 123(1):113-23.

23. Stehberg J, Moraga-Amaro R, Salazar C, Becerra A, Echeverría C, Orellana JA, Bultynck G, Ponsaerts R, Leybaert L, Simon F, Sáez JC, Retamal MA. Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala. FASEB J. 2012. 26(9):3649-57.

24. Bennett MV, Garré JM, Orellana JA, Bukauskas FF, Nedergaard M, Sáez JC. Connexin and pannexin hemichannels in inflammatory responses of glia and neurons. Brain Res. 2012. 1487:3-15.

25. Quintanilla RA, Orellana JA, von Bernhardi R. Understanding Risk Factors for Alzheimer’s Disease: Interplay of Neuroinflammation, Connexin-based Communication and Oxidative Stress. Arch Med Res. 2012. 43:632-44.

26. Orellana JA, Velasquez S, Williams DW, Sáez JC, Berman JW, Eugenin EA. Pannexin1 hemichannels are critical for HIV infection of human primary CD4+ T lymphocytes. J Leukoc Biol. 2013. 94(3):399-407.

27. Sáez PJ, Orellana JA, Vega-Riveros N, Figueroa VA, Hernández DE, Castro JF, Klein AD, Jiang JX, Zanlungo S, Sáez JC. Disruption in connexin-based communication is associated with intracellular Ca²⁺ signal alterations in astrocytes from Niemann-Pick type C mice. PLoS One. 2013. 8(8):e71361.

28. Orellana JA*, Montero TD, von Bernhardi R. Astrocytes inhibit nitric oxide-dependent Ca(2+) dynamics in activated microglia: Involvement of ATP released via pannexin 1 channels. Glia. 2013. 61(12):2023-37.

29. Orellana JA*, Martinez AD, Retamal MA. Gap junction channels and hemichannels in the CNS: Regulation by signaling molecules. Neuropharmacology. 2013. 75:567-82.

30. Orellana JA, Sáez JC, Bennett MV, Berman JW, Morgello S, Eugenin EA. HIV increases the release of dickkopf-1 protein from human astrocytes by a Cx43 hemichannel-dependent mechanism. J Neurochem. 2014. 128(5):752-63.

31. Orellana JA*, Avendaño BC and Montero TD. Role of Connexins and Pannexins in Ischemic Stroke. Curr. Med. Chem. 2014; 21(19):2165-82.

32. Orellana JA, Stehberg J. Hemichannels: new roles in astroglial function. Front Physiol. 2014. 17;5:193.

33. Yesilaltay A, Dokshin GA, Busso D, Wang L, Galiani D, Chavarria T, Vasile E, Quilaqueo L, Orellana JA, Walzer D, Shalgi R, Dekel N, Albertini DF, Rigotti A, Page DC, Krieger M. Excess cholesterol induces mouse egg activation and may cause female infertility. Proc Natl Acad Sci U S A. 2014. 111(46):E4972-80.

34. Orellana JA*, Busso D, Ramírez G, Campos M, Rigotti A, Eugenín J and von Bernhardi R. Prenatal nicotine exposure enhances Cx43 and Panx1 unopposed channel activity in brain cells of adult offspring mice fed a high-fat/cholesterol diet. 2014. 8:403.

35. Montero TD, Orellana JA*. Hemichannels: New pathways for gliotransmitter release. Neuroscience. 2015. 286C:45-59.

36. Orellana JA*, Moraga-Amaro R, Díaz-Galarce R, Rojas S, Maturana CJ, Stehberg J, Sáez JC. Restraint stress increases hemichannel activity in hippocampal glial cells and neurons. Front Cell Neurosci. 2015.9:102.  

37. Avendaño BC, Montero TD, Chávez CE, von Bernhardi R, Orellana JA*. Prenatal exposure to inflammatory conditions increases Cx43 and Panx1 unopposed channel opening and activation of astrocytes in the offspring effect on neuronal survival. Glia. 2015. 63:2058-2072.

38. Orellana JA*. Editorial: Single membrane channels formed by connexins or pannexins: focus on the nervous system. Front Cell Neurosci. 2015 Oct 15;9:402.

39. del Rio R. Quintanilla R, Orellana JA and Retamal MA. Neuron-glia crosstalk in the autonomic nervous system and its possible role in the progression of metabolic syndrome: A new hypothesis. Front. Physiol. 2015. 6:350.

40.  Orellana JA*. Physiological functions of glial cell hemichannels. Adv Exp Med Biol. 2016. 949:93-108.

41. Orellana JA, Retamal MA, Moraga-Amaro R, Stehberg J. Role of Astroglial Hemichannels and Pannexons in Memory and Neurodegenerative Diseases. Front Integr Neurosci. 2016. Jul 20;10:26.

42. Gajardo-Gómez R, Labra VC, Orellana JA*. Connexins and pannexins: new insights into microglial functions and dysfunctions. Front Mol Neurosci. 2016. 9:86.

43. Gajardo-Gómez R, Labra VC, Maturana CJ, Shoji KF, Santibañez CA, Sáez JC, Giuame C, Orellana JA*. Cannabinoids prevent the amyloid β-induced activation of astroglial hemichannels: a neuroprotective mechanism. Glia. 2017. 65(1):122-137.

44. Orellana JA*, Cerpa W, Carvajal MF, Lerma-Cabrera JM, Karahanian E, Osorio-Fuentealba C, Quintanilla RA. New Implications for the Melanocortin System in Alcohol Drinking Behavior in Adolescents: The Glial Dysfunction Hypothesis. Front Cell Neurosci. 2017.11:90.

45. Tapia-Rojas C, Carvajal FJ, Mira RG, Arce C, Lerma-Cabrera JM, Orellana JA, Cerpa W, Quintanilla RA. Adolescent Binge Alcohol Exposure Affects the Brain Function Through Mitochondrial Impairment. Mol Neurobiol. 2018. 55 (5), 4473-4491.

46. Labra VC, Santibáñez CA, Gajardo-Gómez R., Díaz EF, Gómez GI, Orellana JA*. The Neuroglial Dialog Between Cannabinoids and Hemichannels. Frontiers in Molecular Neuroscience. 2018. 11:79.

47. Sáez JC, Contreras-Duarte S, Gómez GI, Labra VC, Santibañez CA, Gajardo-Gómez R, Avendaño BC, Díaz EF, Montero TD, Velarde V, Orellana JA*. Connexin 43 Hemichannel Activity Promoted by Pro-Inflammatory Cytokines and High Glucose Alters Endothelial Cell Function. Front Immunol. 2018. 9:1899.

48. Avudara V, Retamal MA, Del Rio R, Orellana JA*. Synaptic functions of hemichannels: A double-edged sword. Frontiers in Molecular Neuroscience. 2018. 11:435.

49. Gomez GI, Falcon RV, Maturana CJ, Labra VC, Salgado N, Rojas CA, Oyarzún JE, Cerpa W, Quintanilla RA, Orellana JA*. Heavy alcohol exposure activates astroglial hemichannels and pannexons in the hippocampus of adolescent rats: effects on neuroinflammation and astrocyte arborization. Frontiers in Cellular Neuroscience. 2018 12:472.

50. Vejar S, Oyarzún JE, Retamal MA, Ortiz FC, Orellana JA*. Connexin and pannexin-based channels in oligodendrocytes: implications in brain health and disease. Frontiers in Cellular Neuroscience. 2019 Jan 29;13:3.

51. Díaz EF, Labra VC, Alvear TF, Mellado LA, Inostroza CA, Oyarzún JE, Salgado N, Quintanilla RA, Orellana JA*. Connexin 43 hemichannels and pannexin-1 channels contribute to the α-synuclein-induced dysfunction and death of astrocytes. Glia. 2019;67(8):1598-1619.

52. Chávez CE, Oyarzún JE, Avendaño BC, Mellado LA, Inostroza CA, Alvear TF, Orellana JA*. The Opening of Connexin 43 Hemichannels Alters Hippocampal Astrocyte Function and Neuronal Survival in Prenatally LPS-Exposed Adult Offspring. Front Cell Neurosci. 2019 Oct 11;13:460.

53. Flores-Bastías O, Gómez GI, Orellana JA, Karahanian E.Activation of Melanocortin-4 Receptor by a Synthetic  Agonist Inhibits Ethanol induced Neuroinflammation in Rats. Curr Pharm Des. 2019;25(45):4799-4805.

54. Gajardo-Gómez R, Santibañez CA, Labra VC, Gómez GI, Eugenin EA, Orellana JA. HIV gp120 Protein Increases the Function of Connexin 43 Hemichannels and Pannexin-1 Channels in Astrocytes: Repercussions on Astroglial Function. Int J Mol Sci. 2020 Apr 3;21(7):2503.

55. Sáez JC, Contreras-Duarte S, Labra VC, Santibañez CA, Mellado LA, Inostroza CA, Alvear TF, Retamal MA, Velarde V, Orellana JA*. Interferon-γ and high glucose-induced opening of Cx43 hemichannels causes endothelial cell dysfunction and damage. Biochim Biophys Acta Mol Cell Res. 2020 Apr 14;1867(8):118720.

56. Sáez JC, Vargas AA, Hernández DE, Ortiz FC, Giaume C, Orellana JA*. Permeation of Molecules through Astroglial Connexin 43 Hemichannels Is Modulated by Cytokines with Parameters Depending on the Permeant Species. Int J Mol Sci. 2020 Jun 1;21(11):3970.

57. Klionsky DJ et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 2021 Jan;17(1):1-382.

58. Di Cesare Mannelli L, Ceruti S, Orellana JA. Editorial: Astrocytes, a Kaleidoscope of Diversities, a Pharmacological Horizon. Front Pharmacol. 2021 Mar 8;12:638239.

59. Lucero CM, Prieto-Villalobos J, Marambio-Ruiz L, Balmazabal J, Alvear TF, Vega M, Barra P, Retamal MA, Orellana JA, Gómez GI. Hypertensive Nephropathy: Unveiling the Possible Involvement of Hemichannels and Pannexons. Int J Mol Sci. 2022 Dec 14;23(24):15936. doi: 10.3390/ijms232415936. PMID: 36555574; PMCID: PMC9785367